Consanguinity and disease coincidence
نویسندگان
چکیده
منابع مشابه
Consanguinity and the risk of congenital heart disease.
Consanguineous unions have been associated with an increased susceptibility to various forms of inherited disease. Although consanguinity is known to contribute to recessive diseases, the potential role of consanguinity in certain common birth defects is less clear, particularly since the disease pathophysiology may involve genetic and environmental/epigenetic factors. In this study, we ask whe...
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Background. Consanguineous marriage is strongly favored in many regions of the world, despite the prevalent Western belief that the progeny of close kin unions experience developmental disorders and premature mortality. Objective. We outline an alternative perspective on the association between consanguinity and disease, in terms of life history theory and the developmental origins of health an...
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Aim: An increased prevalence of celiac disease (CD) in cystic fibrosis (CF) has been discussed. The aim of this survey was to determine the prevalence of a genetic predisposition to CD in CF-patients compared to the general population. Methods: Celiac serology and HLA-DQ2/ -DQ8 screening was performed in 190 CF-patients at the CF-Center Cologne, Germany. Informed consent was obtained from all p...
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ژورنال
عنوان ژورنال: Eye
سال: 2003
ISSN: 0950-222X,1476-5454
DOI: 10.1038/sj.eye.6700307